Polynucleotides
Polynucleotides represent one of the most significant advances in regenerative aesthetics in recent years. Rather than adding volume or temporarily masking the signs of ageing, they work at a cellular level – stimulating the skin’s own fibroblast cells to produce new collagen and elastin, and restoring the biological foundations of healthy skin.
The result is not a dramatic transformation. It is a genuine improvement in skin quality: tighter, more hydrated, more resilient skin that looks and behaves as it should.
How It Works
Polynucleotides are long-chain DNA fragments derived from highly purified biological sources. When injected into the dermis, they act on fibroblast cells, stimulating increased production of collagen and elastin and actively supporting tissue repair and regeneration.
Their high viscoelasticity means the skin regains its natural bounce and resilience. Like Profhilo, the product spreads from injection points to treat the dermis across the entire region, rather than remaining localised. Treatment involves a series of injections across the target area, with results developing progressively over the course of the treatment schedule.
Dr Shabri offers both Plinest and Ameela – two of the most clinically established polynucleotide formulations available — and will recommend the most appropriate product for your concerns at consultation.
Treatment Areas
Polynucleotides can rejuvenate multiple areas, including:
Face
Improves texture, elasticity, and hydration while addressing fine lines, loss of firmness, dullness, uneven tone, and mild scarring.
Neck & Décolletage
Revitalises crepey or sagging skin by encouraging collagen production, leaving the neck firmer, smoother, and more rejuvenated.
Eyes
Reduces dark circles, fine lines, and thinning skin by stimulating collagen and elastin, restoring brightness and a more rested look.
Scalp for Hair Loss
(to support hair follicle
regeneration and hair loss concerns)
Full Face
Neck & Décolletage
Eyes
(ideal if unsuitable for
tear trough filler)
Scalp for Hair Loss
(to support hair follicle
regeneration and hair loss concerns)
Benefits You Can Expect
Stimulates new collagen and elastin production
Deep skin hydration and improved texture
Reduction in fine lines and crepiness
Improved skin elasticity and bounce
Lifts and tightens areas of laxity
Brightens and revitalises overall complexion
Suitable for face, neck, and delicate eye area
Treatment Overview
Expected Results
Progressive improvement in skin quality, hydration, and firmness across the treatment course
Procedure Time
15 minutes
Anaesthesia
Topical numbing cream available; discomfort level low
Downtime
Minimal — occasional mild redness or swelling
Longevity
6–9 months; repeat course recommended every 6–9 months
Sessions Required
3 sessions, 2 weeks apart
FAQs
What is the difference between Plinest and Ameela
Both are high-quality polynucleotide formulations with strong clinical evidence. Dr Shabri assess your skin concerns and goals at consultation to determine which is most appropriate for you.
Can polynucleotides be combined with other treatments?
Yes, they are frequently combined with dermal fillers or anti-wrinkle in the same appointment.
How often can I have polynucleotides?
The standard schedule is three sessions two weeks apart, repeated every six to nine months. Some patients benefit from more frequent maintenance — every three months — which is equally safe.
Is the eye area treatment different?
Plinest Eyes is a formulation specifically designed for the periorbital area, addressing crepiness and laxity around the eyes where standard injectables are not appropriate.
Who is suitable for polynucleotides?
Ready to rejuvenate your skin from within?
Contact us today to arrange your polynucleotides consultation with Dr Shabri.